Zachary R. Lewis

I'm a PhD student in the Hanken Laboratory at Harvard University. My research concerns the evolution of development. In particular, I am interested in how organogenesis is evolutionarily and ecologically patterned.

What I Do

I am interested in the evolution and development of vertebrate morphology, with an emphasis on the development of ecologically-relevant traits. I focus on organogenesis because organ development is a highly integrative process in which I can simultaneously explore evolution, development, and ecology. Currently I am a graduate student in the Hanken Lab at Harvard University 

Lung development in lungless salamanders. What are the developmental and genetic mechanisms that account for lunglessness in salamanders? Most salamanders have undergone an evolutionary loss of lungs. There is little known about how such a loss is genetically or developmentally achieved.

Pleiotropic interactions between the lungs and heart in the development of the cardio-pulmonary system. Does lung loss have pleiotropic effects on the development of the heart? Despite clear circulatory changes that must accompany lung loss, there is little information on the associated changes to the heart and how these changes may be developmentally patterned.

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CV

complete cv available here

Publications

McCarroll MN, Lewis ZR, Culbertson MD, Martin BL, Kimelman D, Nechiporuk AV. 2012. Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation. Development 139: 2740-2750. [link] [supplement] [pdf]

Culbertson MA, Lewis ZR, Nechiporuk AV. 2011. Chondrogenic and Gliogenic Subpopulations of Neural Crest Play Distinct Roles During the Assembly of Epibranchial Ganglia. PLoS ONE 6(9): e24443. doi:10.1371/journal.pone.0024443 [pdf]

Lewis ZR, McClellan MC, Postlethwait JH, Cresko WA, Kaplan RH. 2008. Female-Specific Increase in Primordial Germ Cells Marks Sex Differentiation in Threespine Stickleback (Gasterosteus aculeatus). Journal of Morphology 269(8): 909-921. [Cover Article] [pdf]

Lewis ZR. 2006. Proliferation of Primordial Germ Cells and Sex Differentiation in Threespine Stickleback (Gasterosteus aculeatus). Baccalaureate thesis. 113 pages, defended before a panel of faculty.

Selected Grants and Awards

E.E. Williams Award (Society for the Study of Amphibians and Reptiles); 2014

Barbour Award (Museum of Comparative Zoology); 2014

Robert G. Goelet research award (Museum of Comparative Zoology); 2013

First prize, Harvard Integrated Life Sciences Gallery Night; 2013

Sigma Xi Grant-in-Aid of Research; 2013

Kenneth Miyata Award (Museum of Comparative Zoology); 2012

NSF Graduate Research Fellowship; 2011

William F. Milton Fund Award (to Jim Hanken and ZRL); 2011

RIKEN Center for Developmental Biology (CDB) Travel Fellowship; 2010

Phi Beta Kappa; 2007

Class of '21 Award (Reed College); 2007

Betty C. Liu Memorial Biology Research Fellowship (Reed College); 2007

NAS Reed College Summer Research Fellowship; 2006

Selected Posters and Oral Presentations

Lewis ZR, Hanken J. "Take Another Little Piece of My Heart: Convergent heart evolution in independent lineages of lungless salamanders." Oral presentation, 6th Conference on the Biology of Plethodontid Salamanders, Tulsa, OK. Mar. 2014.

Lewis ZR, Hanken J. “Co-evolution of heart and lung development in lungless salamanders.” Poster presentation, Society for Integrative and Comparative Biology annual meeting, Austin, TX. Jan. 2014.

Lewis ZR, Kerney RK, Dorantes J, Hanken J. "Lung Loss: Molecular and Morphological Consequences" Oral presentation, International Congress of Vertebrate Morphology, Barcelona, Spain, July 2013.

Lewis ZR, Kerney RK, Dorantes J, Hanken J. “Extrapulmonary Expression of Surfactant Proteins in Lungless Salamanders.” Poster, Keystone Lung Development, Cancer and Disease Symposium, Taos, NM. Feb. 2013.

Lewis ZR, Kerney RK, Dorantes J, Hanken J. “Genetic and Morphological Vestiges of Lost Lungs in Plethodontid Salamanders.” Oral presentation, Society for Integrative and Comparative Biology annual meeting, San Francisco, CA. Jan. 2013.

Lewis ZR, Kerney RK, Dorantes JA, Hanken J. “Pulmonary surfactant proteins are expressed in lungless salamanders.” Oral presentation, Society for Integrative and Comparative Biology annual meeting, Charleston, SC. January 2012.

Lewis ZR, Kerney RK, Hanken J. “Lung Development in Lungless Salamanders!” Poster, Society for Developmental Biology annual meeting, Chicago, IL. July 2011. doi:10.1016/j.ydbio.2011.05.560

Lewis ZR, Kerney RK, Hanken J. “Lung Development in Lungless Salamanders!” Poster, Keystone Lung Development and Repair Symposium, Santa Fe, NM. February 2011.

Lewis ZR, Nechiporuk AV. “Origins of the Epibranchial Placodes and Ganglia in Zebrafish.” Poster, RIKEN CDB Symposium 2010 “Frontiers in Organogenesis,” Kobe, Japan. March 2010.

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Contact

Zachary R. Lewis
Dept. of Organismic and Evolutionary Biology
and Dept. of Herpetology, Museum of Comparative Zoology
Harvard University
26 Oxford St.
Cambridge, MA 02138

Lab: 617-496-4632
Office: 617-496-4065
Fax: 617-495-5667

zlewis@oeb.harvard.edu