Publications (17 in print)

PubMed Link

Akio Kobayashi, M. Todd Valerius, Joshua W. Mugford, Thomas J. Carroll, Michelle Self, Guillermo Oliver, and Andrew P. McMahon (2008). Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3, 169-81. MCB News Story

Benjamin D. Humphreys, M. Todd Valerius, Akio Kobayashi, Joshua W. Mugford, Savuth Soeung, Jeremy S. Duffield, Andrew P. McMahon, and Joseph V. Bonventre (2008). Intrinsic Epithelial Cells Repair the Kidney after Injury. Cell Stem Cell 2, 284-91.

M. T. Valerius, and A. P. McMahon (2008). Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expression Patterns, 8, 297-306.

In this study, I compared Wnt4 mutant kidneys with wildtype controls to identify genes expressed during morphogenesis of the nephron. Whole mount in situ analysis was done on 217 genes identified as differentially expressed. Genes expressed in renal vesicle and their derivatives, structures absent in the mutant, accounted for the largest number of the observed expression patterns. This study has produced a useful compendium genes expressed during nephrogenesis, has informed the current set of studies and the design of several transgenic lines.

*Park, J.P., *Valerius, M.T., and McMahon, A.P. (2007). Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development 134, 2533-2539. *authors contributed equally

Little, M. H., Brennan, J., Georgas, K., Davies, J. A., Davidson, D. R., Baldock, R. A., Beverdam, A., Bertram, J. F., Capel, B., Chiu, H. S., ...Valerius, M. T., et al. (28 authors) (2007). A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns 7, 680-699.

Cheng, H. T., Kim, M., Valerius, M. T., Surendran, K., Schuster-Gossler, K., Gossler, A., McMahon, A. P. and Kopan, R. (2007). Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 134, 801-11.

Gray, P. A., Fu, H., Luo, P., Zhao, Q., Yu, J., Ferrari, A., Tenzen, T., Yuk, D. I., Tsung, E. F., Cai, Z., Alberta J. A., Cheng L. P., Liu Y., Stenman J. M., Valerius M. T., et al. (22 authors) (2004). Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 306, 2255-2257.

Yu, J., McMahon, A. P., and Valerius, M. T. (2004). Recent genetic studies of mouse kidney development. Curr Opin Genet Dev 14, 550-557.

Valerius, M. T., Patterson, L. T., Feng, Y., and Potter, S. S. (2002). Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney, Proc Natl Acad Sci U S A 99, 8090-5.

Valerius, M. T., Patterson, L. T., Witte, D. P., and Potter, S. S. (2002). Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation, Mech Dev 112, 219-32.

Potter, S. S., Valerius, M. T., and Brunskill, E. W. (2002). Using progenitor cells and gene chips to define genetic pathways, Methods Mol Biol 185, 269-84.

Branford, W. W., Zhao, G., Valerius, M.T., Weinstein, M., Birkenmeier, E. H., Rowe, L. B., Potter, S. S. (1997) Spx1, a novel X-linked homeobox gene expressed during spermatogenesis. Mech. Dev. 65: 87-98.

Haynes, T., Thomas, M.B., Dusing, M.R., Valerius, M.T., Potter, S.S. and Wiginton, D. (1996) An enhancer LEF-1/TCF-1 site is essential for insertion-site independent transgene expression in thymus. Nucleic Acids Res. 24:5034-44.

Li, H., Zeitler, P.S., Valerius, M.T., Small, K., Potter, S.S. (1996) Gsh-1, an orphan Hox gene, is required for normal pituitary development. EMBO 15: 714-724.

Valerius, M.T., Li, H., Stock, J.L., Weinstein, M., Kaur, S., Singh, G. and Potter, S.S. (1995) Gsh-1: A novel murine homeobox gene expressed in the central nervous system. Dev. Dyn. 203: 337-351.

Aronow, B.J., Ebert, C.A., Valerius, M.T., Potter, S.S., Wiginton, D.A., Witte, D.P. and Hutton, J.J. (1995) Dissecting a locus control region: Facilitation of enhancer function by extended enhancer-flanking sequences. Mol. Cell Bio. 15: 1123-1135.

Kern, M.J., Witte, D.P., Valerius, M.T., Aronow, B.J. and Potter, S.S. (1992) A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nucleic Acids Research 20: 5189-95.