I am currently a postdoctoral fellow in the Zhuang lab at Harvard University.

<download academic CV>



Work done by titin protein folding assists muscle contraction
Rivas-Pardo JA, Eckels EC, Popa I, Kosuri P, Linke WA, Fernandez JM
Cell Reports 14:1339-1347 (2016)

S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding
Alegre-Cebollada J*, Kosuri P*, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, Warren CM, Solaro RJ, Linke WA, Fernandez JM (*equal contribution)
Cell 156:1235-46 (2014) cover story

Picomolar Amyloid-β Peptides Enhance Spontaneous Astrocyte Calcium Transients
Lee L, Kosuri P, Arancio O
Journal of Alzheimer's Disease 38:49-62 (2013)

Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy
Popa I*, Kosuri P*, Alegre-Cebollada J, Garcia-Manyes S, Fernández JM (*equal contribution)
Nature Protocols 8:1261-76 (2013)

Protein folding drives disulfide formation
Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Ingles-Prieto A, Badilla C, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernandez JM
Cell 151:794-806 (2012)

Direct observation of disulfide isomerization in a single protein
Alegre-Cebollada J, Kosuri P, Rivas-Pardo JA, Fernández JM
Nature Chemistry 3:882-7 (2011)

Protease power strokes force proteins to unfold
Alegre-Cebollada J, Kosuri P, Fernandez JM
Cell 145:339-340 (2011)

Single-molecule paleoenzymology probes the chemistry of resurrected enzymes
Perez-Jimenez R, Ingles-Prieto A, Zhao Z, Sanchez-Romero I, Alegre-Cebollada J, Kosuri P, Garcia-Manyes S, Kappock TJ, Tanokura M, Holmgren A, Sanchez-Ruiz JM, Gaucher EA, Fernandez JM
Nature Structural & Molecular Biology, 18:592-596 (2011)

Kalman filter estimates of the contour length of an unfolding protein in single-molecule force spectroscopy experiments
Fernandez VI, Kosuri P, Parot P, Fernandez JM
Review of Scientific Instruments 80:113104 (2009)

Single-molecule force spectroscopy approach to enzymatic catalysis
Alegre-Cebollada J, Perez-Jimenez R, Kosuri P, Fernandez JM
Journal of Biological Chemistry, 285:18961-6 (2009)

Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion
O’Connell NE, Grey MJ, Tang Y, Kosuri P, Miloushev VZ, Raleigh DP, Palmer AG
Journal of Biomolecular NMR, 45:85-98(2009)

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy
Perez-Jimenez R, Li J, Kosuri P, Berne BJ, Fernandez JM
Nature Structural & Molecular Biology, 16:890-6 (2009)

Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis
Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM
Journal of Biological Chemistry, 283:27121-29 (2008)

Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation
Fei J, Kosuri P, MacDougall DD, Gonzalez RL
Molecular Cell, 30:348-359 (2008)

Development of a RILIS ionisation scheme for gold at ISOLDE, CERN
Marsh BA, Fedosseev VN, Kosuri P
Hyperfine Interactions, 171:109-116 (2006)