Publications

253.

“Concerted nucleophilic aromatic substitutions,” Kwan, E.E.; Zeng, Y.; Besser, H.A.; Jacobsen, E.N. Nature Chem.  2018, doi: 10.1038/s41557-018-0079-7

252.

“Quaternary Stereocenters via an Enantioconvergent Catalytic SN1 Reaction,” Wendlandt, A.E.; Vangal, P.; Jacobsen, E.N. Nature  2018, 556 , 447-451.

251.

“Catalytic Diastereo-and Enantioselective Fluoroamination of Alkenes,” Mennie, K.M., Banik, S.M.; Reichert, E.C., Jacobsen, E.N. J.Am.Chem.Soc.  2018, 140 , 4797-4802. doi: 10.1021/jacs.8b02143.

250.

“Lewis Acid Enhancement by Hydrogen-Bond Donors for Asymmetric Catalysis,” Banik, S.M.; Levina, A.; Hyde, A. M.; Jacobsen, E.N. Science  2017, 358 , 761-764. doi: 10.1126/science.aao5894.

249.

“Chiral Thioureas Promote Enantioselective Pictet–Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction,” Klausen, R. S.; Kennedy, C. R.; Hyde, A. M.; Jacobsen, E.N J. Am. Chem. Soc.  2017, 139 , 12299-12309. doi: 10.1021/jacs.7b06811

248.

“Catalytic 1,3-Difunctionalization via Oxidative C–C Bond Activation,” Banik, S.M.; Mennie, K.; Jacobsen, E.N. J. Am. Chem. Soc.  2017, 139, 9152-9155. doi: 10.1021/jacs.7b05160

247.

“Sensitive and Accurate 13C Kinetic Isotope Effect Measurements Enabled by Polarization Transfer,” Kwan, E.E.; Park, Y.; Besser, H.A.; Anderson, T.L.; Jacobsen, E.N. J. Am. Chem. Soc.  2017, 139 (1) , 43-46. doi: 10.1021/jacs.6b10621

246.

“Macrocyclic Bis-Thioureas Catalyze Stereospecific Glycosylation Reactions,” Park, Y.; Harper, K.C.; Kuhl, N.; Kwan, E.E.; Liu, R.Y.; Jacobsen, E.N. Science 2017, Vol. 355, Issue 6321, 162-166. doi: 10.1126/science.aal1875

245.

“Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-bond Donor and Lewis Base,” Park, Y.; Schindler, C.S.; Jacobsen, E.N. J. Am. Chem. Soc. 2016, 138, 14848-14851. doi: 10.1021/jacs.6b09736

244.

“Enantioselective, Catalytic Fluorolactonization Reactions with a Nucleophilic Fluoride Source,” Woerly, E.M.; Banik, S.M.; Jacobsen, E.N. J. Am. Chem. Soc.  2016, 138, 13858-13861. doi: 10.1021/jacs.6b09499

243.

“Mechanism-Guided Development of a Highly Active, Dimeric Thiourea Catalyst for Anion-Abstraction Catalysis,” Kennedy, C.R.; Lehnherr, D.; Rajapaksa, N.S.; Ford, D.D.; Park, Y.; Jacobsen, E.N. J. Am. Chem. Soc.  2016, 138, 13525-13528. doi: 10.1021/jacs.6b09205

242.

“Conformational Control of Chiral Amido-Thiourea Catalysts Enables Improved Activity and Enantioselectivity,” Lehnherr, D.; Ford, D.D.; Bendelsmith, A.; Kennedy, C.R.; Jacobsen, E.N. Org. Lett. 2016, 18, 3214-3217. doi: 10.1021/acs.orglett.6b01435

241.

“Anion-Abstraction Catalysis: The Cooperative Mechanism of α-Chloroether Activation by Dual H-Bond Donors,” Ford, D.D.; Lehnherr, D.; Kennedy, C.R.; Jacobsen, E.N. ACS Catal. 2016, 6, 4616-4620. doi: 10.1021/acscatal.6b01384

240.

“On-and Off-Cycle Catalyst Cooperativity in Anion-Binding Catalysis,” Ford, D.D.; Lehnherr, D.; Kennedy, C.R.; Jacobsen, E.N. J. Am. Chem. Soc. 2016, 138, 7860-7863. doi: 10.1021/jacs.6b04686

239.

“Organometallic Chemistry: A New Metathesis,” Hennessy, E.T.; Jacobsen, E.N. Nature Chem.  2016, 8, 741-742. doi: 10.1038/nchem.2581

238.

“Catalytic Asymmetric Difluorination of Alkenes to Generate Difluoromethylated Stereocenters,” Banik, S.M.; Medley, J.W.; Jacobsen, E.N. Science 2016, 353, 51-54. doi: 10.1126/science.aaf8078

237.

“Synergistic Ion-Binding Catalysis Demonstrated via an Enantioselective, Catalytic [2,3]-Wittig Rearrangement, ” Kennedy, C.R.; Guidera, J.A.; Jacobsen, E.N. ACS Cent. Sci.  2016, 2, 416-423. doi: 10.1021/acscentsci.6b00125

236.

“Catalytic, Diastereoselective 1,2-Difluorination of Alkenes,” Banik, S.M.; Medley, J.W.; Jacobsen, E. N. J. Am. Chem. Soc.  2016, 138,5000-5003. doi: 10.1021/jacs.6b02391

235.

“The cation-π Interaction in Small-Molecule Catalysis” Kennedy, C.R.; Lin, S.; Jacobsen, E. N. Angew. Chem. Int. Ed. ,in press. doi: 10.1002/anie.201600547R1(Review)

234.

“Activation of Electron-Deficient Quinones through Hydrogen-Bond-Donor-Coupled Electron Transfer,” Turek, A.K.; Hardee, D.M.; Ullman, A.; Nocera, D.C.; Jacobsen, E. N. Angew. Chem. Ed. 2016, 55,539-544 [Angew. Chem. 2016128,549-554] doi: 10.1002/anie.201508060

233.

“A Simple Primary Amine Catalyst for Enantioselective α-Hydroxylations and α-Fluorinations of Branched Aldehydes,” Witten, M.R.; Jacobsen, E. N. Organic Lett. doi: 10.1021/acs.orglett.5b01193.

232.

“Enantioselective synthesis of tertiary α-chloro esters by non-covalent catalysis,” Liu, R.Y.; Wasa, M.; Jacobsen, E. N. Tetrahedron Lett. 2015, 56,3428-3430 (Special issue honoring Harry Wasserman) doi: 10.1016/j.tetlet.2015.01.124

231.

“Highly Enantioselective, Intermolecular Hydroamination of Allenyl Esters Catalyzed by Bifunctional Phosphinothioureas,” Fang, Y.-Q.; Tadross, P.M.; Jacobsen, E.N. J. Am. Chem. Soc. 2014, 136, 17966-17968 doi: 10.1021/ja5117638 [Supporting Information]

230.

“Enantioselective Selenocyclization via Dynamic Kinetic Resolution of Seleniranium Ions by Hydrogen-Bond Donor Catalysts” Zhang, H.; Lin, S.; Jacobsen, E. N. J. Am. Chem. Soc. 2014, 136, 16485-16488 doi: 10.1021/ja510113s [Supporting Information]

229.

Jacobsen, E. N.; Zuend, S. J. "Compound reagents and method for synthesizing enantiomerically enriched amino acids," U.S. Patent #8859812, October 14, 2014.

228.

“Thiourea-Catalyzed Enantioselective Addition of Indoles to Pyrones: Alkaloid Cores with Quaternary Carbons” Yeung, C. S.; Ziegler, R. E.; Porco, J. A., Jr.; Jacobsen, E. N. J. Am. Chem. Soc. 2014, 136, 13614-13617 doi: 10.1021/ja508523g [Supporting Information]

227.

“Asymmetric Mannich Synthesis of α-Amino esters by Anion-Binding Catalysis” Wasa, M,; Liu, R. Y.; Roche, S. P.; Jacobsen, E. N. J. Am. Chem. Soc. 2014, 136, 12872-12875 doi: 10.1021/ja5075163 [Supporting Information]

226.

“Chiral sulfinamidourea and strong Brønsted acid–cocatalyzed enantioselective Povarov reaction to access tetrahydroquinolines” Xu, H.; Zhang, H.; Jacobsen, E. N. Nat. Protoc. 2014, 9, 1860-1866 doi: 10.1038/nprot.2014.125.

225.

“Catalytic Asymmetric Synthesis of 8-Oxabicyclooctanes by Intermolecular [5+2] Pyrylium Cycloadditions” Witten, M. R.; Jacobsen, E. N. Angew. Chem. Int. Ed. 2014, 53, 5912-5916 doi: 10.1002/anie.201402834. [Supporting Information]

224.

“A broadly applicable and practical oligomeric salen(Co) catalyst for enantioselective epoxide ring-opening reactions,” White, D. E.; Tadross, P. M.; Lu, Z.; Jacobsen, E. N. Tetrahedron 2014, 70, 4165-4180 doi: 10.1016/j.tet.2014.03.043.

223.

“Photoredox Activation and Anion-Binding in the Dual Catalytic Enantioselective Synthesis of β-Amino Esters” Bergonzini, G.; Schindler, C. S.; Wallentin, C.-J.; Jacobsen, E. N.; Stephenson, C. R. J. Chem. Sci. 2014, 5, 112-116 doi: 10.1039/C3SC52265B. [Supporting Information]

222.

“Mechanistic Basis for High Selectivity and Broad Substrate Scope in the (salen)Co(III)-Catalyzed Hydrolytic Kinetic Resolution” Ford, D. D.; Nielsen, L. P. C.; Zuend, S. J.; Musgrave, C. B.; Jacobsen, E. N. J. Am. Chem. Soc. 2013,135, 15595-15608 doi: 10.1021/ja408027p. [Supporting Information]

221.

“Enantioselective Catalytic Transannular Ketone Ene Reactions”  Rajapaksa, N.S.; Jacobsen, E. N. Org. Lett. 2013, 15, 4238–4241.  [Supporting Information]

220.

“A Practical Method for the Synthesis of Highly Enantioenriched trans-1,2-Amino Alcohols” Birrell, J. A.; Jacobsen, E. N. Org. Lett. 2013, 15, 2895–2897.  [Supporting Information]

219.

“A New Twist on Cooperative Catalysis”  Schindler, C. S.; Jacobsen, E. N. Science 2013, 340, 1052–1053 (Perspective).

218.

“Enantioselective Thiourea-Catalyzed Intramolecular Cope-Type Hydroamination” Brown, A. R.; Uyeda, C.; Brotherton, C. A.; Jacobsen, E. N. J. Am. Chem. Soc. 2013, 135, 6747–6749. [Supporting Information]

217.

“Chiral β-Iodoamines by Urea-Catalysed Iodocyclization of Trichloroacetimidates”  Brindle, C. S.; Yeung, C. S.; Jacobsen, E. N.  Chem. Sci. 2013, 4, 2100–2104.  [Supporting Information]

216.

“Enantioselective Formal Aza-Diels–Alder Reactions of Enones with Cyclic Imines Catalyzed by Primary Aminothioureas” Lalonde, M. P.; McGowan, M. A.; Rajapaksa, N. S.; Jacobsen, E. N. J. Am. Chem. Soc. 2013, 135, 1891–1894. [Supporting Information]

215.

“Enantioselective Total Synthesis of (+)-Reserpine” Rajapaksa, N. S.; McGowan, M. A.; Rienzo, M.; Jacobsen, E. N. Org. Lett. 2013, 15, 706–709.  [Supporting Information]

214.

“Asymmetric Ion-Pairing Catalysis”  Brak, K.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2013, 52, 534–561.

213.

“Remodelling by diversity and design”  Tadross, P. M.; Jacobsen, E. N. Nature Chem. 2012, 4, 963–965 (News & Views).

212.

“Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahyroquinoline Library”  Gerard, B; O’Shea, M. W.; Donckele, E.; Kesavan, S.; Akella, L. B.; Xu, H.; Jacobsen, E. N.; Marcaurelle, L. A. ACS Comb. Sci. 2012, 14, 621–630. [Supporting Information]

211.

“Thiourea-catalysed ring opening of episulfonium ions with indole derivatives by means of stabilising, non-covalent interactions”  Lin, S.; Jacobsen, E. N. Nature Chem. 2012, 4, 817–824. [Supporting Information]

210.

“Catalysis in Tight Spaces” Burns, N. Z.; Jacobsen, E. N. Nature 2012, 483, 278–279 (News & Views).

209.

“Mechanistic Basis for High Reactivity of (salen)Co-OTs in the Hydrolytic Kinetic Resolution of Terminal Epoxides” Nielsen, L. P. C.; Zuend, S. J.; Ford, D. D.; Jacobsen, E. N. J. Org. Chem. 2012, 77, 2486–2495. [Supporting Information]

208.

"Thiourea-Catalyzed Enantioselective Iso-Pictet–Spengler Reactions” Lee, Y.; Klausen, R. S.; Jacobsen, E. N. Org. Lett. 2011, 13, 5564–5567. [Supporting Information]

207.

"Dual Catalysis in Enantioselective Oxidopyrylium-Based [5 + 2] Cycloadditions” Burns, N. Z.; Witten, M. R.; Jacobsen, E. N. J. Am. Chem. Soc. 2011, 133, 14578–14581. [Supporting Information]

206.

"Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis" Birrell, J. A.; Desrosiers, J.-N.; Jacobsen, E. N. J. Am. Chem. Soc. 2011, 133, 13872–13875. [Supporting Information]

205.

"Chiral Sulfinamide/Achiral Sulfonic Acid Cocatalyzed Enantioselective Protonation of Enol Silanes" Beck, E. M.; Hyde A. M.; Jacobsen E. N. Org. Lett. 2011, 13, 4260–4263. [Supporting Information]

204.

"Transition State Charge Stabilization Through Multiple Non-Covalent Interactions in the Guanidinium-Catalyzed Enantioselective Claisen Rearrangement"  Uyeda, C.; Jacobsen, E. N. J. Am. Chem. Soc. 2011, 133, 5062–5075. [Supporting Information]

203.

"Catalytic Enantioselective Claisen Rearrangements of O-Allyl β-Ketoesters"  Uyeda, C.; Rötheli, A. R.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2010, 49, 9753–9756. [Supporting Information]

202.

Burns, N. Z.; Jacobsen, E. N. Mannich Reaction. In Stereoselective Synthesis 2: Stereoselective Reactions of Carbonyl and Imino Groups; Molander, G., Ed.; Georg Thieme Verlag: New York, 2010; Chapter 2.16.

201.

"Organocatalysis" Jacobsen, E. N.; MacMillan, D. W. C. Proc. Natl. Acad. Sci. USA 2010, 107, 20618–20619.

200.

"Attractive Non-Covalent Interactions in Asymmetric Catalysis: Links Between Enzymes and Small-Molecule Catalysts" Knowles, R. R.; Jacobsen, E. N. Proc. Natl. Acad. Sci. USA 2010, 107, 20678–20685.

199.

"Tertiary Aminourea-Catalyzed Enantioselective Iodolactonization" Veitch, G. E.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2010, 49, 7332–7335.  [Supporting Information]

198.

"Enantioselective Catalytic α-Alkylation of Aldehydes via an SN1 Pathway" Brown, A. R.; Kuo, H.-S.; Jacobsen, E. N. J. Am. Chem. Soc. 2010, 132, 9286–9288.  [Supporting Information]

197.

"An Enantioselective Total Synthesis of (+)-Peloruside A" McGowan, M. A.; Stevenson, C. P.; Schiffler, M. A.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2010, 49, 6147–6150. [Supporting Information]

196.

"Enantioselective Thiourea-Catalyzed Cationic Polycyclizations” Knowles, R. R.; Lin, S.; Jacobsen, E. N. J. Am. Chem. Soc. 2010, 132, 5030–5032. [Supporting Information]

195.

"Asymmetric Cooperative Catalysis of Strong Brønsted Acid-Promoted Reactions Using Chiral Ureas” Xu, H.; Zuend, S. J.; Woll, M. P.; Tao, Y.; Jacobsen, E. N. Science 2010, 327, 986–990. [Supporting Information]

194.

"Mechanism of Amido-Thiourea Catalyzed Enantioselective Imine Hydrocyanation: Transition State Stabilization via Multiple Non-Covalent Interactions"  Zuend, S. J., Jacobsen, E. N. J. Am. Chem. Soc. 2009, 131, 15358–15374. [Supporting Information]

193.

"Scaleable catalytic asymmetric Strecker syntheses of unnatural α-amino acids" Zuend, S. J.; Coughlin, M. P.; Lalonde, M. P.; Jacobsen, E. N. Nature 2009, 461, 968–970. [Supporting Information]

192.

"Enantioselective, Thiourea-Catalyzed Intermolecular Addition of Indoles to Cyclic N-Acyl Iminium Ions" Peterson, E. A.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2009, 48, 6328–6331. [Supporting Information]

191.

"Bifunctional Asymmetric Catalysis with Hydrogen Chloride: Enantioselective Ring Opening of Aziridines Catalyzed by a Phosphinothiourea" Mita, T.; Jacobsen, E. N. Synlett  2009, 1680–1684 (Special Cluster Issue on Cooperative Catalysis).

190.

"Enantioselective Intramolecular Openings of Oxetanes Catalyzed by (salen)Co(III) Complexes: Access to Enantioenriched Tetrahydrofurans" Loy, Rebecca N.; Jacobsen, E. N. J. Am. Chem. Soc. 2009, 131, 2786–2787. [Supporting Information]

189.

"Weak Brønsted Acid-Thiourea Co-catalysis: Enantioselective, Catalytic Protio-Pictet–Spengler Reactions" Klausen, R. S.; Jacobsen, E. N. Org. Lett. 2009, 11, 887–890. [Supporting Information]

188.

"Structural Analysis of Spiro β-Lactone Proteasome Inhibitors" Groll, M.; Balskus, E. P.; Jacobsen, E. N.  J. Am. Chem. Soc. 2008, 130, 14981–14983. [Supporting Information]

187.

"Asymmetric Intramolecular Arylcyanation of Unactivated Olefins via C–CN Bond Activation”  Watson, M. P.; Jacobsen, E. N.  J. Am. Chem. Soc. 2008, 130, 12594–12595. [Supporting Information]

186.

"Enantioselective Claisen Rearrangements with a Hydrogen-Bond Donor Catalyst"  Uyeda, C.; Jacobsen, E. N.  J. Am. Chem. Soc. 2008, 130, 9228–9229. [Supporting Information]

185.

"Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions" Reisman, S. E.; Doyle, A. G.; Jacobsen, E. N. J. Am. Chem. Soc. 2008, 130, 7198–7199. [Supporting Information]

184.

"Cooperative, Highly Enantioselective Phosphinothiourea Catalysis of Imine-Allene [3+2] Cycloadditions" Fang, Y.-Q.; Jacobsen, E. N. J. Am. Chem. Soc. 2008, 130, 5660–5661. [Supporting Information]

183.

"Regio- and Enantioselective Cyclization of Pyrroles onto N-Acyliminium Ions" Raheem, I. T.; Thiara, P. V.; Jacobsen, E. N.  Org. Lett. 2008, 10, 1577–1580. [Supporting Information]

182.

"Cooperative Catalysis in the Hydrolytic Kinetic Resolution of Epoxides by Chiral [(salen)CoIII] Complexes Immobilized on Gold Colloids"  Belser, T.; Jacobsen, E. N.  Adv. Synth. Catal. 2008, 350, 967–971.

181.

"Catalytic Asymmetric Total Synthesis of (+)-Yohimbine" Mergott, D. J.; Zuend, S. J.; Jacobsen, E. N. Org. Lett. 2008, 10, 745–748. [Supporting Information]

180.

"Dimeric (salen)Al Complexes Display Expanded Scope in the Conjugate Cyanation of a β-Unsaturated Imides" Mazet, C.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2008, 47, 1762–1765. [Supporting Information]

179.

"Enantioselective Catalytic Carbonyl-ene Cyclization Reactions" Grachan, M. L.; Tudge, M. T.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2008, 47, 1469–1472. [Supporting Information]

178.

"Small-Molecule H-Bond Donors in Asymmetric Catalysis"  Doyle, A. G.; Jacobsen, E. N.  Chem. Rev. 2007, 107, 5713–5743.

177.

"Cooperative Catalysis by Tertiary Amino-Thioureas: Mechanism and Basis for Enantioselectivity of Ketone Cyanosilylation" Zuend, S. J.; Jacobsen, E. N.  J. Am. Chem. Soc. 2007, 129, 15872–15883. [Supporting Information]

176.

"Enantioselective Pictet–Spengler-Type Cyclizations of Hydroxylactams: H-Bond Donor Catalysis by Anion Binding" Raheem, I. T.; Thiara, P. V.; Peterson, E. A.; Jacobsen, E. N.  J. Am. Chem. Soc. 2007, 129, 13404–13405. [Supporting Information]

175.

"Asymmetric Catalysis of the Transannular Diels–Alder Reaction" Balskus, E. P.; Jacobsen, E. N. Science 2007, 317, 1736–1740. [Supporting Information]

174.

"Enantioselective Alkylation of Acyclic α,α-Disubstituted Tributyltin Enolates Catalyzed by a {Cr(salen)} Complex" Doyle, A. G.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2007, 46, 3701–3705. [Supporting Information]

173.

"Indium-Mediated Asymmetric Allylation of Acylhydrazones Using a Chiral Urea Catalyst"  Tan, K. L.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2007, 46, 1315–1317. [Supporting Information]

172.

"Alk-2-enoic Acid Esters” Vanderwal, C. D.; Jacobsen, E. N. Science of Synthesis 2006, 20b, 1305–1340.

171.

"Arenecarboxylic Acid Esters" Yoon, T. P.; Jacobsen, E. N.  Science of Synthesis 2006, 20b, 1285–1304.

170.

"Alk-2-enoic Acids" Vanderwal, C. D.; Jacobsen, E. N.  Science of Synthesis 2006, 20a, 551–568.

169.

"Arenecarboxylic Acids" Yoon, T. P.; Jacobsen, E. N.  Science of Synthesis 2006, 20a, 533–549.

168.

"Preparation of (S)-Methyl Glycidate via Hydrolytic Kinetic Resolution" Stevenson, C. P.; Nielsen, L. P. C. Jacobsen, E. N. Org. Synth. 2006, 83, 162–166.

167.

"A Chiral Primary Amine-Thiourea Catalyst for the Highly Enantioselective Direct Conjugate Addition of α,α-Disubstituted Aldehydes to Nitroalkenes"  Lalonde, M. P.; Chen, Y.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2006, 45, 6366–6370. [Supporting Information]

166.

"Highly Enantioselective Direct Conjugate Addition of Ketones to Nitroalkenes Promoted by A Chiral Primary Amine-Thiourea Catalyst" Huang, H.; Jacobsen, E. N. J. Am. Chem. Soc. 2006, 128, 7170–7171. [Supporting Information]

165.

"α,β-Unsaturated β-Silyl Imide Substrates for Catalytic, Enantioselective Conjugate Additions: A Total Synthesis of (+)-Lactacystin and the Discovery of a New Proteasome Inhibitor" Balskus, E. P.; Jacobsen, E. N. J. Am. Chem. Soc. 2006, 128, 6810–6812. [Supporting Information]

164.

"Asymmetric Catalysis by Chiral Hydrogen Bond Donors" Taylor, M. S.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2006, 45, 1520–1543.

163.

Nielsen, L. P. C. Jacobsen, E. N. Catalytic, Asymmetric Epoxide Ring-Opening Chemistry. In Aziridines and Epoxides in Organic Synthesis; Yudin, A., Ed.; Wiley: New York, 2006; Chapter 10.

162.

"An Efficient, Highly Diastereo- and Enantioselective Hetero-Diels-Alder Catalyst. Preparation of (2S,6R)-6-(tert-Butyldimethylsilyloxymethyl)-2-Methoxy-2,5-Dihydropyran" Chavez, D. E.; Jacobsen, E. N.  Org. Synth. 2005, 82, 34–42.

161.

"Highly Enantioselective Aza-Baylis–Hillman Reactions Catalyzed by Chiral Thiourea Derivatives" Raheem, I. T.; Jacobsen, E. N.  Adv. Synth. Catal. 2005, 347, 1701–1708.  [Supporting Information]

160.

"Enantioselective Thiourea-Catalyzed Acyl-Mannich Reactions of Isoquinolines" Taylor, M. S.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2005, 44, 6700–6704. [Supporting Information]

159.

"Efficient Total Syntheses of (–)-Colombiasin A and (–)-Elisapterosin B: Application of the Cr-Catalyzed Asymmetric Quinone Diels–Alder Reaction" Boezio, A. A.; Jarvo, E. R.; Lawrence, B. M.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2005, 44, 6046–6050.  [Supporting Information]

158.

"Highly Enantio- and Regioselective Quinone Diels–Alder Reactions Catalyzed by a Tridentate (Schiff Base)Cr(III) Complex" Jarvo, E. R.; Lawrence, B. M.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2005, 44, 6043–6046.  [Supporting Information]

157.

"Thiourea-Catalyzed Enantioselective Cyanosilylation of Ketones" Fuerst, D. E.; Jacobsen, E. N.  J. Am. Chem. Soc. 2005, 127, 8964–8965.  [Supporting Information]

156.

Wenzel, A. G.; Jacobsen, E. N. Asymmetric Catalysis in the Enantioselective Synthesis of β-Amino Acids. In Enantioselective Synthesis of beta-Amino Acids; Juaristi, E., Soloshonok, V., Eds.; Wiley-VCH: New York, 2005; Chapter 4.

155.

"Highly Enantioselective Catalytic Conjugate Addition of N-Heterocycles to α,β-Unsaturated Ketones and Imides" Gandelman, M.; Jacobsen, E. N. Angew. Chem., Int. Ed. 2005, 44, 2393–2397.  [Supporting Information]

154.

"Highly Enantioselective Conjugate Additions to α,β-Unsaturated Ketones Catalyzed by a (salen)Al Complex"  Taylor, M. S.; Zalatan, D. N.; Lerchner, A. M.; Jacobsen, E. N.  J. Am. Chem. Soc. 2005, 127, 1313–1317.  [Supporting Information]

153.

Jacobsen, E. N.; Sigman, M. S. Main Group Metal-Based Asymmetric Catalysts and Applications Thereof.  U.S. Patent #6844448, January 18, 2005.

152.

"Highly Enantioselective Thiourea-catalyzed Nitro-Mannich Reaction" Yoon, T. P.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2005, 44, 466–468.  [Supporting Information]

151.

"Enantioselective Alkylations of Tributyltin Enolates Catalyzed by Cr(salen)Cl: Access to Enantiomerically Enriched All Carbon Quaternary Centers"  Doyle, A. G.; Jacobsen, E. N.  J. Am. Chem. Soc. 2005, 127, 62–63.  [Supporting Information]

150.

Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F.  Hydrolytic Kinetic Resolution of Cyclic Substrates.  U.S. Patent #6800766, October 5, 2004.

149.

"Highly Enantioselective Hydration of α,β-Unsaturated Imides by Al-Catalyzed Conjugate Addition of Oxime Nucleophiles"  Vanderwal, C. D.; Jacobsen, E. N.  J. Am. Chem. Soc. 2004, 126, 14724–14725.  [Supporting Information]

148.

"Highly Enantioselective Catalytic Acyl-Pictet–Spengler Reactions"  Taylor, M. S.; Jacobsen, E. N.  J. Am. Chem. Soc. 2004, 126, 10558–10559.  [Supporting Information]

147.

"Cooperative Dual Catalysis: Application to the Highly Enantioselective Conjugate Cyanation of Unsaturated Imides"  Sammis, G. M.; Danjo, H.; Jacobsen, E. N.  J. Am. Chem. Soc. 2004, 126, 9928–9929.  [Supporting Information]

146.

"General Catalytic Synthesis of Highly Enantiomerically Enriched Terminal Aziridines from Racemic Epoxides"  Kim, S.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2004, 43, 3952–3954.  [Supporting Information]

145.

"Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes”  Larrow, J. F.; Jacobsen, E. N.  Top. Organomet. Chem. 2004, 6, 123–152.

144.

Jacobsen, E. N.; Sigman, M. S.  Parallel Combinatorial Approach to the Discovery and Optimization of Catalysts and Uses Thereof.  U.S. Patent #6709824 B2, March 23, 2004.

143.

"Asymmetric Catalysis in Complex Target Synthesis"  Taylor, M. S.; Jacobsen, E. N.  Proc. Nat. Acad. Sci. USA  2004, 101, 5368–5373.

142.

"Thiourea-Catalyzed Enantioselective Hydrophosphonylation of Imines: Practical Access to Enantiomerically Enriched α-Amino Phosphonic Acids"  Joly, G. D.; Jacobsen, E. N.  J. Am. Chem. Soc. 2004, 126, 4102–4103.  [Supporting Information]

141.

Liu, Y.; DiMare, M.; Marchese, S. A.; Jacobsen, E. N.; Jasmin, S.  Hydrolytic Kinetic Resolution of Epoxides.  U.S. Patent #6693206, February 17, 2004.

140.

"Mechanistic Investigation Leads to a Synthetic Improvement in the Hydrolytic Kinetic Resolution of Terminal Epoxides"  Nielsen, L. C. P.; Stevenson, C. P.; Blackmond, D.G.; Jacobsen, E. N.  J. Am. Chem. Soc. 2004, 126, 1360–1362.  [Supporting Information]

139.

"Catalytic Asymmetric Total Syntheses of Quinine and Quinidine"  Raheem, I. T.; Goodman, S. N.; Jacobsen, E. N.  J. Am. Chem. Soc. 2004, 126, 706–707.  [Supporting Information]

138.

"Asymmetric Hydrocyanation of Hydrazones Catalyzed by Lanthanide - PYBOX Complexes”  Keith, J. M.; Jacobsen, E. N.  Org. Lett. 2004, 6, 153–155.  [Supporting Information]

137.

Vachal, P.; Jacobsen, E. N.  Cyanation of Carbonyl and Imino Groups.  In Comprehensive Asymmetric Catalysis (1st Supplement); Jacobsen, E. N., Pfaltz, A., Yamamoto, H., Eds.; Springer: New York, 2003; Chapter 28.

136.

"New Oligomeric Catalyst for the Hydrolytic Kinetic Resolution of Terminal Epoxides Under Solvent-Free Conditions"  White, D. E.; Jacobsen, E. N. Tetrahedron: Asymm.  2003, 14, 3633–3638.  

135.

"Asymmetric Hetero-Ene Reactions of Trimethylsilyl Enol Ethers Catalyzed by Tridentate Schiff Base Chromium(III) Complexes"  Ruck, R. T.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2003, 42, 4771–4774.  [Supporting Information]

134.

"Divergent Stereoinduction Mechanisms in Urea-Catalyzed Additions to Imines"  Wenzel, A. G.; Lalonde, M. P.; Jacobsen, E. N.  Synlett 2003, 12, 1919–1922.

133.

"Enantioselective Michael Additions to α,β-Unsaturated Imides Catalyzed by a Salen-Al Complex"  Taylor, M. S.; Jacobsen, E. N.  J. Am. Chem. Soc. 2003, 125, 11204–11205.  [Supporting Information]

132.

"Catalyst-Controlled Inverse Electron Demand Hetero-Diels–Alder Reactions in the Enantio- and Diastereoselective Synthesis of Iridoid Natural Products"  Chavez, D. E.; Jacobsen, E. N.  Org. Lett. 2003, 5, 2563–2565.  [Supporting Information]

131.

Jacobsen, E. N.; Sigman, M. S.  Main Group Metal-Based Asymmetric Catalysts and Applications Thereof.  U.S. Patent #6521561, February 18, 2003.

130.

"Highly Enantioselective, Catalytic Conjugate Addition of Cyanide to α,β-Unsaturated Imides"  Sammis, G. M.; Jacobsen, E. N.  J. Am. Chem. Soc. 2003, 125, 4442–4443.  [Supporting Information]

129.

"Privileged Chiral Catalysts"  Yoon, T. P.; Jacobsen, E. N.  Science 2003, 299, 1691–1693.

128.

"Enantiopure β-Hydroxy Morpholine Amides From Terminal Epoxides via Carbonylation at 1 Atm”  Goodman, S. N.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2002, 41, 4703–4705.  [Supporting Information]

127.

"The Simplest 'Enzyme'"  Movassaghi, M.; Jacobsen, E. N.  Science 2002, 298, 1904–1905 (Perspective).

126.

"Asymmetric Catalytic Mannich Reactions Catalyzed by Urea Derivatives: Enantioselective Synthesis of β-Aryl-β-Amino Acids"  Wenzel, A. G.; Jacobsen, E. N.  J. Am. Chem. Soc. 2002, 124, 12964–12965.  [Supporting Information]

125.

"A Practical Synthesis of α,β-Unsaturated Imides, Useful Substrates For Asymmetric Conjugate Addition Reactions"  Goodman, S. N.; Jacobsen, E. N.  Adv. Synth. Catal. 2002, 344, 953–956.

124.

Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F.  Hydrolytic Kinetic Resolution of Cyclic Substrates.  U.S. Patent #6448414, September 10, 2002.

123.

"Structure-Based Analysis and Optimization of a Highly Enantioselective Catalyst for the Strecker Reaction"  Vachal, P.; Jacobsen, E. N.  J. Am. Chem. Soc. 2002, 124, 10012–10014.  [Supporting Information]

122.

Jacobsen, E. N.; Francis, M. B.; Finney, N. S.  Combinatorial Approach for Generating Novel Coordination Complexes.  U.S. Patent #6489093, December 3, 2002.

121.

"Highly Enantioselctive Inverse Electron Demand Hetero-Diels–Alder Reactions of α,β-Unsaturated Aldehydes"  Gademann, K.; Chavez, D. E.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2002, 41, 3059–3061.  [Supporting Information]

120.

Jacobsen, E. N.; Schaus, S. E.; Dossetter, A. G.; Jamison, T. F.  Asymmetric Cycloaddition Reactions.  U.S. Patent #6369223, April 9, 2002.

119.

"Catalyst-Controlled Diastereoselective Hetero-Diels–Alder Reactions"  Joly, G. D.; Jacobsen, E. N.  Org. Lett. 2002, 4, 1795–1798.  [Supporting Information]

118.

"A Practical Oligomeric (salen)Co Catalyst for Asymmetric Epoxide Ring Opening Reactions"  Ready, J. R.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2002, 41, 1374–1377.  [Supporting Information]

117.

"Asymmetric Catalysis of Hetero-Ene Reactions with Tridentate Schiff Base Chromium(III) Complexes"  Ruck, R. T.; Jacobsen, E. N.  J. Am. Chem. Soc. 2002, 124, 2882–2883.  [Supporting Information]

116.

"A Direct Method for the Conversion of Terminal Epoxides into γ-Butanolides"  Movassaghi, M.; Jacobsen, E. N.  J. Am. Chem. Soc. 2002, 124, 2456–2457.  [Supporting Information]

115.

"Highly Selective Hydrolytic Kinetic Resolution of Terminal Epoxides Catalyzed by Chiral (salen)Cobalt(III)-Complexes. Practical Synthesis of Enantioenriched Terminal Epoxides and 1,2-Diols"  Schaus, S. E.; Brandes, B. D; Larrow, J. F.; Tokunaga, M.; Hansen, K. B.; Gould, A. E.; Furrow, M. E.; Jacobsen, E. N.  J. Am. Chem. Soc. 2002, 124, 1307–1315.  [Supporting Information]

114.

Jacobsen, E. N.; Sigman, M. S.  Parallel Combinatorial Approach to the Discovery and Optimization of Catalysts and Uses Thereof.  U.S. Patent #6316616, November 13, 2001.

113.

"Total Synthesis of (+)-Ambruticin"  Liu, P.; Jacobsen, E. N.  J. Am. Chem. Soc. 2001, 123, 10772–10773.  [Supporting Information]

112.

"FR901464: Total Synthesis, Proof of Structure, and Evaluation of Synthetic Analogs"  Thompson, C. F.; Jamison, T. F.; Jacobsen, E. N.  J. Am. Chem. Soc. 2001, 123, 9974–9983.  [Supporting Information 1, Supporting Information 2]

111.

"Total Synthesis of Fostriecin (CI-920)"  Chavez, D. E.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2001, 40, 3667–3670.  [Supporting Information]

110.

Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F.  Hydrolytic Kinetic Resolution of Cyclic Substrates.  U.S. Patent #6262278 B1, July 17, 2001.

109.

"Synthetically Useful, Self-Assembling MMO Mimic System for Catalytic Alkene Epoxidation with Aqueous H2O2"   White, M. C.; Doyle, A. G.; Jacobsen, E. N.  J. Am. Chem. Soc. 2001, 123, 7194–7195.  [Supporting Information]

108.

"Regioselective Ring Opening of Enantiomerically Enriched Epoxides via Catalysis with Chiral (Salen)Cr(III) Complexes"  Brandes, B. D.; Jacobsen, E. N.  Synlett 2001, 1013–1015.

107.

Jacobsen, E. N.; Schaus, S. E.; Dossetter, A. G.; Jamison, T. F.  Asymmetric Cycloaddition Reactions.  U.S. Patent #6211370, April 3, 2001.

106.

"Highly Active Oligomeric (salen)Co Catalysts for Asymmetric Epoxide Ring Opening Reactions"  Ready, J. M.; Jacobsen, E. N.  J. Am. Chem. Soc. 2001, 123, 2687–2688.  [Supporting Information]

105.

"Practical Synthesis of a Soluble Schiff Base Catalyst for the Asymmetric Strecker Reaction"  Su, J. T.; Vachal, P.; Jacobsen, E. N.  Adv. Synth. Catal. 2001, 343, 197–200.

104.

"Practical Considerations in Kinetic Resolution Reactions"  Keith, J. M.; Larrow, J. F.; Jacobsen, E. N.  Adv. Synth. Catal. 2001, 343, 5–26.

103.

"Total Synthesis of FR901464.Convergent Assembly of Chiral Components Prepared by Asymmetric Catalysis"  Thompson, C. F.; Jamison, T. F.; Jacobsen, E. N.  J. Am. Chem. Soc. 2000, 122, 10482–10483.  [Supporting Information]

102.

Jacobsen, E. N.; Schaus, S. E.  Asymmetric Cycloaddition Reactions.  U.S. Patent #6130340, October 10, 2000.

101.

"Cooperative Asymmetric Catalysis with Dendrimeric Co(salen) Complexes"  Breinbauer, R.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2000, 39, 3604–3607.

100.

"Asymmetric Catalysis of Epoxide Ring-Opening Reactions"  Jacobsen, E. N.  Acc. Chem. Res. 2000, 33, 421–431.

99.

"Asymmetric Ring-Opening of Meso-Epoxides with TMSCN Catalyzed by (pybox)Lanthanide Complexes"  Schaus, S. E.; Jacobsen, E. N.  Org. Lett. 2000, 2, 1001–1004.  [Supporting Information]

98.

"Enantioselective Catalytic Addition of HCN to Ketoimines.Catalytic Synthesis of Quaternary Amino Acids"  Vachal, P.; Jacobsen, E. N.  Org. Lett. 2000, 2, 867–870.  [Supporting Information]

97.

"A General Catalyst for the Asymmetric Strecker Reaction"   Sigman, M. S.; Vachal, P.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 2000, 39, 1279–1281.  [Supporting Information]

96.

"Nickel Comes Full Cycle"  Jacobsen, E. N.; Breinbauer, R.  Science 2000, 287, 437–438 (Perspective).

95.

"Enantioselective Ring-opening of meso Aziridines Catalyzed by Tridentate Schiff-base Chromium(III) Complexes"  Li, Z.; Fernandez, M.; Jacobsen, E. N.  Org. Lett. 1999, 1, 1611–1613.  [Supporting Information]

94.

"Enantioselective Parallel Synthesis Using Polymer-Supported Chiral Co(Salen) Complexes"  Peukert, S.; Jacobsen, E. N.  Org. Lett. 1999, 1, 1245–1248.  [Supporting Information]

93.

Jacobsen, E. N.  Future Perspectives in Asymmetric Catalysis.  In Comprehensive Asymmetric Catalysis; Jacobsen, E. N., Pfaltz, A., Yamamoto, H., Eds.; Springer: New York, 1999; Chapter 42.

92.

Jacobsen, E. N.  Aziridination.  In Comprehensive Asymmetric Catalysis; Jacobsen, E. N., Pfaltz, A., Yamamoto, H., Eds.; Springer: New York, 1999; Chapter 17.

91.

Jacobsen, E. N.; Wu, M. H.  Ring Opening of Epoxides and Related Reactions.  In Comprehensive Asymmetric Catalysis; Jacobsen, E. N., Pfaltz, A., Yamamoto, H., Eds.; Springer: New York, 1999; Chapter 35.

90.

Jacobsen, E. N.; Wu, M. H.  Epoxidation of Alkenes Other than Allylic Alcohols.  In Comprehensive Asymmetric Catalysis; Jacobsen, E. N., Pfaltz, A., Yamamoto, H., Eds.; Springer: New York, 1999; Chapter 18.2.

89.

"Asymmetric Synthesis of β-Amino Acid Derivatives via Catalytic Conjugate Addition of Hydrazoic Acid to Unsaturated Imides"  Myers, J. K.; Jacobsen, E. N.  J. Am. Chem. Soc. 1999, 121, 8959–8960.  [Supporting Information]

88.

"Chromium Catalyzed Kinetic Resolution of 2,2-Disubstituted Epoxides"  Lebel, H.; Jacobsen, E. N.  Tetrahedron Lett. 1999, 40, 7303–7306.

87.

"Highly Enantio- and Diastereoselective Hetero-Diels–Alder Reactions Catalyzed by New Chiral Tridentate Chromium Catalysts"  Dossetter, A. G.; Jamison, T. F.; Jacobsen, E. N.  Angew. Chem.,  Int. Ed. 1999, 38, 2398–2400.

86.

Jacobsen, E. N.; Martinez, L. E.; Leighton, J. L.  Stereoselective Ring Opening Reactions.  U.S. Patent #5929232, July 27, 1999.

85.

"Regio- and Enantioselective Cyclization of Epoxy Alcohols Catalyzed by a [CoIII(salen)] Complex"  Wu, M. H.; Hansen, K. B.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 1999, 38, 2012–2014.

84.

"Asymmetric Catalytic Synthesis of α-Aryloxy Alcohols: Kinetic Resolution of Terminal Epoxides via Highly Enantioselective Ring Opening with Phenols"  Ready, J. M.; Jacobsen, E. N.  J. Am. Chem. Soc. 1999, 121, 6086–6087.  [Supporting Information 1, Supporting Information 2]

83.

Senanayake, C. H.; Jacobsen, E. N.  Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis.  In Process Chemistry in the Pharmaceutical Industry; Gadamasetti, K. G., Ed.; Dekker: New York, 1999; pp. 347–368.

82.

"Polymer-Supported Chiral Co(Salen) Complexes: Synthetic Applications and Mechanistic Investigations in the Hydrolytic Kinetic Resolution of Terminal Epoxides"  Annis, D. A.; Jacobsen, E. N.  J. Am. Chem. Soc. 1999, 121, 4147–4154.

81.

"Discovery of Novel Catalysts for Alkene Epoxidation Using Metal-Binding Combinatorial Libraries"  Francis, M. B.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 1999, 38, 937–941.

80.

"Regioselective Carbomethoxylation of Chiral Epoxides: a New Route to Enantiomerically Pure β-Hydroxyesters" Hinterding, K.; Jacobsen, E.N.  J. Org. Chem. 1999, 64, 2164–2165.  [Supporting Information]

79.

"(1S,2R)-1-Aminoindan-2-ol"  Larrow, J. F.; Roberts, E.; Verhoeven, T. R.; Ryan, K. M.; Senanayake, C. H.; Reider, P. J.; Jacobsen, E. N.  Org. Synth. 1998, 76, 46–56.

78.

"Enantioselective Total Synthesis of Taurospongin A"  Lebel, H.; Jacobsen, E. N.  J. Org. Chem. 1998, 63, 9624–9625.  [Supporting Information 1, Supporting Information 2]

77.

"Carbenoid Insertions into the Silicon-Hydrogen Bond Catalyzed by Chiral Copper (I) Schiff Base Complexes"  Dakin, L. A.; Schaus, S. E.; Jacobsen, E. N.; Panek, J. S.  Tetrahedron Lett. 1998, 39, 8947–8950.

76.

"Cooperative Asymmetric Catalysis Using Dimeric Salen Complexes"  Konsler, R. G.; Karl, J.; Jacobsen, E. N.  J. Am. Chem. Soc. 1998, 120, 10780–10781.  [Supporting Information]

75.

"Practical Access to Highly Enantioenriched C-3 Building Blocks via Hydrolytic Kinetic Resolution"  Furrow, M. E.; Schaus, S. E.; Jacobsen, E. N.  J. Org. Chem. 1998, 63, 6776–6777.  [Supporting Information]

74.

"Solid Phase Synthesis of Cyclic RGD Peptide Derivatives via Asymmetric Catalysis: Stereochemistry as a Diversity Element"  Annis, D. A.; Jacobsen, E. N.  Angew. Chem., Int. Ed. 1998, 37, 1907–1909.

73.

"Asymmetric Ring Opening of Meso Epoxides with Thiols: Enantiomeric Enrichment Using a Bifunctional Nucleophile"  Wu, M. H.; Jacobsen, E. N.  J. Org. Chem. 1998, 63, 5252–5254.  [Supporting Information]

72.

"Total Synthesis of Muconin by Efficient Assembly of Chiral Building Blocks"  Schaus, S. E.; Brånalt, J. E.; Jacobsen, E. N.  J. Org. Chem. 1998, 63, 4876–4877.  [Supporting Information 1, Supporting Information 2]

71.

"Combinatorial Libraries of Transition Metal Complexes, Catalysts, and Materials"  Francis, M. B.; Jamison, T. F.; Jacobsen, E. N.  Curr. Opin. Chem. Biol. 1998, 2, 422–428.

70.

"Enantioselective Addition of Hydrogen Cyanide to Imines Catalyzed by a Chiral (salen)Al(III) Complex"  Sigman, M. S.; Jacobsen, E. N.  J. Am. Chem. Soc. 1998, 120, 5315–5316.  [Supporting Information]

69.

"Schiff Base Catalysts for the Asymmetric Strecker Reaction Identified and Optimized from Parallel Synthetic Libraries"   Sigman, M. S.; Jacobsen, E. N.  J. Am. Chem. Soc. 1998, 120, 4901–4902.  [Supporting Information]

68.

"The Mechanistic Basis for Electronic Effects on Enantioselectivity in the (salen)Mn-Catalyzed Epoxidation Reaction”  Palucki, M.; Finney, N. S.; Pospisil, P. J.; Güler, M. L.; Ishida, T.; Jacobsen, E. N.  J. Am. Chem. Soc. 1998, 120, 948–954.  [Supporting Information]

67.

"Asymmetric Hetero-Diels–Alder Reactions Catalyzed by Chiral (salen)Chromium(III) Complexes"  Schaus, S. E.; Brånalt, J. E.; Jacobsen, E. N.  J. Org. Chem. 1998, 63, 403–405.  [Supporting Information]

66.

"(R,R)-N,N'-Bis(3,5-Di-tert-butylsalicylidene)-1,2- Cyclohexanediaminomanganese (III) Chloride, a Highly Enantioselective Epoxidation Catalyst"  Larrow, J. F.; Jacobsen, E. N.  Org. Synth. 1997, 75, 1–10.

65.

"Synthesis of Enantiopure 3-Chlorostyrene Oxide via an Asymmetric Epoxidation/Hydrolytic Kinetic Resolution Sequence"  Brandes, B. D.; Jacobsen, E. N.  Tetrahedron: Asymm. 1997, 8, 3927–3933.

64.

Jacobsen, E. N.; Martinez, L. E.; Leighton, J. L.  Stereoselective Ring Opening Reactions.  U.S. Patent #5665890, September 9, 1997.

63.

"On the Viability of Metallaoxetane Intermediates in the (salen)Mn-Catalyzed Asymmetric Epoxidation Reaction"  Finney, N. S.; Pospisil, P. J.; Chang, S.; Palucki, M.; Hansen, K. B.; Jacobsen, E. N.  Angew. Chem. Int. Ed. Engl. 1997, 36, 1720–1723.

62.

"Asymmetric Catalysis with Water: Efficient Kinetic Resolution of Terminal Epoxides by Means of Catalytic Hydrolysis"  Tokunaga, M.; Larrow, J. F.; Kakiuchi, F.; Jacobsen, E. N.  Science 1997, 277, 936–938.

61.

Jacobsen, E. N.; Zhang, W.; Deng, L.  Chiral Catalysts and Epoxidation Reactions.  U.S. Patent #5663393, September 2, 1997.

60.

Jacobsen, E. N.; Zhang, W.; Deng, L.  Chiral Catalysts and Epoxidation Reactions Catalyzed Thereby.  U.S. Patent #5637739, June 10, 1997.

59.

"Practical Synthesis of Enantiopure Cyclic 1,2-Aminoalcohols via Catalytic Asymmetric Ring Opening of Meso Epoxides"  Schaus, S. E.; Larrow, J. F.; Jacobsen, E. N.  J. Org. Chem. 1997, 62, 4197–4199.  [Supporting Information]

58.

"An Efficient Formal Synthesis of Balanol via the Asymmetric Epoxide Ring Opening Reaction"  Wu, M. H.; Jacobsen, E. N.  Tetrahedron Lett. 1997, 38, 1693–1696.

57.

"Enantioselective Catalytic Ring Opening of Epoxides with Carboxylic Acids"  Jacobsen, E. N.; Kakiuchi, F.; Konsler, R. G.; Larrow, J. F.; Tokunaga, M.  Tetrahedron Lett. 1997, 38, 773–776.

56.

"On the Mechanism of Asymmetric Nucleophilic Ring-Opening of Epoxides Catalyzed by (Salen)Cr(III) Complexes"  Hansen, K. B.; Leighton, J. L.; Jacobsen, E. N.  J. Am. Chem. Soc. 1996, 118, 10924–10925.  [Supporting Information]

55.

"Dynamic Kinetic Resolution of Epichlorohydrin via Enantioselective Catalytic Ring Opening with TMSN3. Practical Synthesis of Aryl Oxazolidinone Antibacterial Agents"  Schaus, S. E.; Jacobsen, E. N.  Tetrahedron Lett. 1996, 37, 7937–7940.

54.

"Highly Efficient and Enantioselective Synthesis of Carbocyclic Nucleoside Analogs Using Selective Early Transition Metal Catalysis"   Martinez, L. E.; Nugent, W. A.; Jacobsen, E. N.  J. Org. Chem. 1996, 61, 7963–7966.  

53.

"Combinatorial Approach to the Discovery of Novel Coordination Compounds"  Francis, M. B.; Finney, N. S.; Jacobsen, E. N.  J. Am. Chem. Soc. 1996, 118, 8983–8984.  [Supporting Information]

52.

"Enantioselective Binding of Prochiral Olefins to a Chiral Catalyst via Simultaneous Face-Face and Edge-Face Aromatic Interactions"  Quan, R. W.; Li, Z.; Jacobsen, E. N.  J. Am. Chem. Soc. 1996, 118, 8156–8157.  [Supporting Information]

51.

"X-Ray Structural Studies of Highly Enantioselective Mn(salen) Epoxidation Catalysts"  Pospisil, P. J.; Carsten, D. H.; Jacobsen, E. N.  Chem. Eur. J. 1996, 2, 974–980.

50.

"Kinetic Resolution of Terminal Epoxides via Highly Regioselective and Enantioselective Ring Opening with TMSN3. An Efficient, Catalytic Route to 1,2-Aminoalcohols"  Larrow, J. F.; Schaus, S. E.; Jacobsen, E. N.  J. Am. Chem. Soc. 1996, 118, 7420–7421.  [Supporting Information]

49.

"Efficient Synthesis of (R)-4-Trimethylsilyloxy-2- cyclopentenone by Enantioselective Catalytic Epoxide Ring Opening"  Leighton, J. L.; Jacobsen, E. N.  J. Org. Chem. 1996, 61, 389–390.  [Supporting Information]

48.

"Kinetic Resolution of Racemic Chromenes via Asymmetric Epoxidation; Synthesis of (+)-Teretifolione B"  Vander Velde, S. L.; Jacobsen, E. N.  J. Org. Chem. 1995, 60, 5380–5381.  [Supporting Information 1, Supporting Information 2]

47.

"Low Temperature Asymmetric Epoxidation of Unfunctionalized Olefins Catalyzed by (salen)Mn(III) Complexes"  Palucki, M.; McCormick, G. J.; Jacobsen, E. N.  Tetrahedron Lett. 1995, 36, 5457–5460.

46.

"Enantioselective Catalytic Epoxidation of Tetrasubstituted Olefins"  Brandes, B. D.; Jacobsen, E. N.  Tetrahedron Lett. 1995, 36, 5123–5126.

45.

Jacobsen, E. N.  Fundamental and Applied Studies in Asymmetric Oxidation Catalysis.  In Stereoselective Reactions of Metal-Activated Molecules; Werner, H., Sundmeyer, J., Eds.; Vieweg: New York, 1995; pp. 17–26.

44.

Jacobsen, E. N.  Transition Metal Catalyzed Oxidations: Asymmetric Epoxidation.  In Comprehensive Organometallic Chemistry II; Wilkinson, G., Stone, F. G. A., Abel, E. W., Hegedus, L. S., Eds.; Pergamon: New York, 1995; Volume 12; pp. 1097–1135.

43.

"Mechanistic Study of the (diimine)Cu-Catalyzed Asymmetric Azridination of Alkenes. Nitrene Transfer via Ligand-Accelerated Catalysis"  Li, Z.; Quan, R. W.; Jacobsen, E. N.  J. Am. Chem. Soc. 1995, 117, 5889–5890.  [Supporting Information]

42.

"Highly Enantioselective Ring Opening of Epoxides Catalyzed by Chiral (salen)Cr(III) Complexes"  Martínez, L. E.; Leighton, J. L.; Carsten, D. H.; Jacobsen, E. N.  J. Am. Chem. Soc. 1995, 117, 5897–5898.  [Supporting Information]

41.

Jacobsen, E. N.  Sodium Hypochlorite-Chiral Manganese (III) Salen Complexes.  In Encyclopedia of Reagents for Organic Synthesis; Paquette, L. A., Ed.; Wiley: New York, 1995; Volume 7; pp. 4585–4586.

40.

Jacobsen, E. N.; Galvin, J. M.  Sodium Hypochlorite.  In Encyclopedia of Reagents for Organic Synthesis; Paquette, L.A., Ed.; Wiley: New York, 1995; Volume 7; pp. 4580–4585.

39.

"Carbenoid Transfer to Imines: A New Asymmetric Catalytic Synthesis of Aziridines"  Hansen, K. H.; Finney, N. S.; Jacobsen, E. N.  Angew. Chem. Int. Ed. Engl. 1995, 34, 676–678.

38.

"Synthetic and Biological Catalysts for Chemical Synthesis: How to Assess Practical Utility"  Jacobsen, E. N.; Finney, N. S.  Chem. Biol. 1994, 1, 85–90.

37.

"Kinetic Resolution of 1,2-Dihydronaphthalene Oxide and Related Epoxides via Asymmetric C–H Hydroxylation"  Larrow, J. F.; Jacobsen, E. N.  J. Am. Chem. Soc. 1994, 116, 12129–12130.

36.

"Highly Enantioselective, Low Temperature Epoxidation of Terminal Olefins"   Palucki, M.; Pospisil, P. J.; Zhang, W.; Jacobsen, E. N.  J. Am. Chem. Soc. 1994, 116, 9333–9334.  [Supporting Information]

35.

"Highly Enantioselective, Catalytic Epoxidation of Trisubstituted Olefins"  Brandes, B. D.; Jacobsen, E. N.  J. Org. Chem. 1994, 59, 4378–4380.  [Supporting Information]

34.

"Effect of Chiral Quaternary Ammonium Salts on (salen)Mn-Catalyzed Epoxidation of cis-Olefins. A Highly Enantioselective, Catalytic Route to Trans Epoxides"  Chang, S.; Galvin, J. M.; Jacobsen, E. N.  J. Am. Chem. Soc. 1994, 116, 6937–6938.  [Supporting Information]

33.

"A Practical Process for the Large-Scale Preparation of (R,R)-N,N'-Bis(3,5-Di-tert-butylsalicylidene)-1,2-Cyclohexanediaminomanganese (III) Chloride, a Highly Enantioselective Epoxidation Catalyst"  Larrow, J. F.; Jacobsen, E. N.; Gao, Y.; Hong, Y.; Nie, X.; Zepp, C. M.  J. Org. Chem. 1994, 59, 1939–1940.  [Supporting Information]

32.

"Enantioselective Epoxidation of Cyclic 1,3-Dienes Catalyzed by a Sterically and Electronically Optimized (Salen)Mn Complex"  Chang, S.; Heid, R. M.; Jacobsen, E. N.  Tetrahedron Lett. 1994, 35, 669–672.

31.

"Enantioselective Catalytic Epoxidation of Cinnamate Esters"  Jacobsen, E. N.; Deng, L.; Furukawa, Y.; Martínez, L. E.  Tetrahedron 1994, 50, 4323–4334.

30.

"Non-Stereospecific Mechanisms in Asymmetric Addition to Alkenes Result in Enantiodifferentiation after the First Irreversible Step"  Zhang, W.; Lee, N. H.; Jacobsen, E. N.  J. Am. Chem. Soc. 1994, 116, 425–426.  [Supporting Information]

29.

"Regio- and Enantioselective Epoxidation of Conjugated Polyenes. Formal Synthesis of LTA4 Methyl Ester"  Chang, S.; Lee, N. H.; Jacobsen, E. N.  J. Org. Chem. 1993, 58, 6939–6941.  [Supporting Information]

28.

"Synthesis and Characterization of Chiral Bimetallic Complexes Bearing Hard and Soft Lewis Acidic Sites"  Fields, L. B.; Jacobsen, E. N.  Tetrahedron: Asymm. 1993, 4, 2229–2240.

27.

Jacobsen, E. N.  Asymmetric Catalytic Epoxidation of Unfunctionalized Olefins.  In Catalytic Asymmetric Synthesis; Ojima, I., Ed.; VCH: New York, 1993; Chapter 4.2.

26.

"Encouraging Tomorrow's Chemists: University Outreach Program Bringing Hands-On Experiments to Local Students"  Heinze, K. F.; Allen, J. L.; Jacobsen, E. N.  J. Chem. Ed. 1995, 72, 167–169.

25.

"Highly Enantioselective Epoxidation of Disubstituted Alkenes with Hydrogen Peroxide Catalyzed by Chloroperoxidase"  Allain, E. A.; Hager, L. P.; Deng, L.; Jacobsen, E. N.  J. Am. Chem. Soc. 1993, 115, 4415–4416.  [Supporting Information]

24.

"Asymmetric Alkene Aziridination with Readily Available Chiral Diimine-Based Catalysts"  Li, Z.; Conser, K. R.; Jacobsen, E. N.  J. Am. Chem. Soc. 1993, 115, 5326–5327.  [Supporting Information]

23.

"Salen-Manganese Complexes are Superoxide Dismutate Mimics"  Baudry, M.; Etienne, S.; Bruce, A.; Palucki, M.; Jacobsen, E.; Malfroy, B.  Biochem. Biophys. Res. Commun. 1993, 192, 964–968.

22.

"Asymmetric Oxidation of Sulfides with H2O2-Catalyzed by (salen)Mn(III) Complexes"  Palucki, M.; Hanson, P.; Jacobsen, E. N.  Tetrahedron Lett. 1992, 33, 7111–7114.

21.

"A Substoichiometric Pyridine•Lithium Enolate Complex: Solution and X-Ray Data, and Implications to Catalysis in the Aldol Reaction"  Pospisil, P. J.; Jacobsen, E. N.  J. Am. Chem. Soc. 1992, 114, 7585–7587.  [Supporting Information]

20.

"A Practical, Highly Enantioselective Synthesis of the Taxol Side Chain via Asymmetric Catalysis"  Deng, L.; Jacobsen, E. N.  J. Org. Chem. 1992, 57, 4320–4323.

19.

"Enantioselective Epoxidation of Conjugated Dienes and Enynes. Trans-Epoxides from Cis-Olefins"  Lee, N. H.; Jacobsen, E. N.  Tetrahedron Lett. 1991, 32, 6533–6536.

18.

"Enantiomerically Pure Epoxychromans via Asymmetric Catalysis"  Lee, N. H.; Muci, A. R.; Jacobsen, E. N.  Tetrahedron Lett. 1991, 32, 5055–5058.

17.

Jacobsen, E. N.  Asymmetric Synthesis.  In 1992 Yearbook of Science & Technology; McGraw-Hill, Inc.: New York, 1991; p 34.

16.

"Electronic Tuning of Asymmetric Catalysts"  Jacobsen, E. N.; Güler, M. L.; Zhang, W.  J. Am. Chem. Soc. 1991, 113, 6703–6704.

15.

"Mechanistic Study of a Synthetically Useful Mono-oxygenase Model Using Hypersensitive Probes cis and trans-2-phenyl-1-Vinylcyclopropane"  Fu, H.; Look, G. C.; Zhang, W.; Jacobsen, E. N.; Wong, C.-H.  J. Org. Chem. 1991, 56, 6497–6500.  [Supporting Information]

14.

"Highly Enantioselective Epoxidation Catalysts Derived from 1,2-Diaminocyclohexane"  Jacobsen, E. N.; Zhang, W.; Muci, A. R.; Ecker, J. R.; Deng, L.  J. Am. Chem. Soc. 1991, 113, 7063–7064.  [Supporting Information]

13.

"Asymmetric Epoxidation with Sodium Hypochlorite Catalyzed by Readily Available Chiral Mn(III) Salen Complexes"  Zhang, W.; Jacobsen, E. N.  J. Org. Chem. 1991, 56, 2296–2298.  [Supporting Information]

12.

"Preparation of trans-1,2-Diamino-1,2-Dimethylcyclohexane via Highly Stereoselective Olefin Oxidation by Dinitrogen Tetroxide"  Zhang, W.; Jacobsen, E. N.  Tetrahedron Lett. 1991, 32, 1711–1714.

11.

"Enantioselective Epoxidation of Unfunctionalized Olefins Catalyzed by (salen)Manganese Complexes"  Zhang, W.; Loebach, J. L.; Wilson, S. R.; Jacobsen, E. N.  J. Am. Chem. Soc. 1990, 112, 2801–2803.

10.

"On the Structure of Osmium Tetroxide-Cinchona Alkaloid Complexes"  Svendsen, J. S.; Markó, I. E.; Jacobsen, E. N.; Pulla Rao, Ch.; Bott, S.; Sharpless, K. B.  J. Org. Chem. 1989, 54, 2263.

9.

"A Mechanistic Insight Leads to a Greatly Improved Osmium-Catalyzed Asymmetric Dihydroxylation Process"  Wai, J. S. M.; Markó, I. E.; Svendsen, J. S.; Finn, M. G.; Jacobsen, E. N.; Sharpless, K. B.  J. Am. Chem. Soc. 1989, 111, 1123.

8.

"Kinetic Role of Alkaloid Ligands in Asymmetric Catalytic Dihydroxylation" Jacobsen, E. N.; Markó, I. E.; France, M. B.; Svendsen, J. S.; Sharpless, K. B.  J. Am. Chem. Soc. 1989, 111, 737.

7.

"Rapid, Reversible Intramolecular C–H Oxidative Addition and H-Exchange in a Heterodinuclear 'Early-Late' Transition Metal Complex"  Jacobsen, E. N.; Goldberg, K. I.; Bergman, R. G.  J. Am. Chem. Soc. 1988, 110, 3706.

6.

"Asymmetric Dihydroxylation via Ligand-Accelerated Catalysis" Jacobsen, E. N.; Markó, I. E.; Mungall, W. S.; Schröder, G. W.; Sharpless, K. B.  J. Am. Chem. Soc. 1988, 110, 1968.

5.

"Synthesis of Organometallic Heterodinuclear µ-Oxo Complexes by Extrusion of Alkenes from Zirconium/Tungsten Oxaalkyl Complexes" Jacobsen, E. N.; Trost, M. K.; Bergman, R. G.  J. Am. Chem. Soc. 1986, 108, 8092.

4.

"Synthesis and Chemistry of a Bridging Vinylidenedicobalt Complex. Evidence for a Non-Chain Radical Mechanism in its Reaction with Metal Hydrides to Give Heteronuclear Clusters" Jacobsen, E. N.; Bergman, R. G.  J. Am. Chem. Soc. 1985, 107, 2023.

3.

"Steric Effects on the Titanium Tetrachloride-Promoted Dimerization of Silyl Ketene Acetals" Jacobsen, E. N.; Totten, G. E.; Wenke, G.; Karydas, A. C.; Rhodes, Y. E.  Synth. Commun. 1985, 15, 301.

2.

"Synthesis, Crystal and Molecular Structure, and Reactions of the Bridging Vinylidenedicobalt Complex (µ-CCH2)(CpCoCO)2. Reaction with Molybdenum Hydrides to Give a Heteronuclear Cluster Complex" Jacobsen, E. N.; Bergman, R. G.  Organometallics 1984, 3, 329.

1.

"Silyl Ketene Acetal Chemistry: Steric Limitations in Lewis Acid-Promoted Addition of Ketones" Wenke, G.; Jacobsen, E. N.; Totten, G. E.; Karydas, A. C.; Rhodes, Y. E.  Synth. Commun. 1983, 13, 449.