Dr. Anita Goel

 

 

goel@physics.harvard.edu

 

M.D., Harvard-MIT, Division of Health Sciences and Technology

Ph.D., M.A., Harvard University, Physics

B.S., Stanford University, Physics

 

Research Interests

Honors

Professional Service

Teaching

Publications

Talks

Research Interests

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  • Develop Experimentally Testable Conceptual Frameworks and Theoretical Models to Describe Molecular Motors Dynamics Along DNA.
  • Experimentally Probe the Real-Time Single Molecule Dynamics of Molecular Motors that Read DNA.

Honors

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Professional Service

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1.       Fellow, World Technology Network, New York, NY

2.       Fellow-at-Large, Santa Fe Institute, Santa Fe, NM

3.       Chair, Emergence, Life, and Related Topics, Science and Ultimate Reality Symposium,
Plainsboro, NJ, May, 2002.

4.       Panel Chair, Emerging Technologies that Could Help Save the Environment, World Technology
Summit, London, UK, July 1-2, 2001.

5.       Founder, organizer and chair, nine-week Summer School on Polymer Physics and the Biology of Macromolecules. Co-sponsored by Harvard- MIT HST & Rowland Institute for Science, Summer 1997.

6.       Chair, think tank meeting, Physics of DNA, Rowland Institute for Science, Cambridge, MA, July, 1997.

7.       Founding chair, SETU (Setu is Sanskrit for “bridge”), a humanitarian and visionary organization dedicated to building new high-tech, economic, and socio-political bridges between the U.S. and India. Keynote speaker, 3-day international conference at Stanford University.

Teaching

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1.       Teaching Fellow, Foundations of Modern 20th Century Physics, Harvard, 2001.

2.       “Optical and Magnetic Manipulation of DNA and other Polymers,” Summer School on Polymer Physics and the Biology of Macromolecules. Co-sponsored by Harvard-MIT HST & Rowland Institute for Science, Summer 1997.

Selected Publications

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1.       I. Andricioaei, A. Goel, D.R. Herschbach and M. Karplus, “Dependence of DNA polymerase replication rate on external forces: A model based on molcular dynamics simulations,” Biophysics J., 87, 2004.

2.       A. Goel, R.D. Astumian and D.R. Herschbach,“Tuning and Swtiching a DNA Polymerase Motor with Mechanical Tension,” in Proc. of the National Academy of Science, USA, 100, 17, pp. 9699-9704, August 2003.

3.       A. Goel and D.R. Herschbach, “Controlling the Speed and Direction of Molecular Motors that Replicate DNA,” in Fluctuations and Noise in Biological, Biophysical and Biomedical Systems, Proc. of SPIE, 5110, pp. 63-68, 2003.

4.       A. Goel, T. Ellenberger, M.D. Frank-Kamenetskii and D. Herschbach, “Unifying Themes in DNA Replication: Reconciling Single Molecule Kinetic Studies with Structrual Data on DNA Polymerases,” J. Biolmolecular Structure and Dynamics, (Cover), 19, 4, 2002.

5.       A. Goel, M.D. Frank-Kamenetskii, T. Ellenberger and D. Herschbach, “Tuning DNA ‘Strings’: Modulating the Rate of DNA Replication with Mechanical Tension,” Proc. of the National Academy of Science, USA, 98, 15, pp. 8485-8489.

6.       A. Goel, “The Physics of Life” paper presented at the Science and Ultimate Reality Symposium, Young Researcher’s Competition in Honor of John Archibald Wheeler, Princeton, New Jersey, March, 2002. See Also Physics Today -May, 2002.

Selected Talks

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University Colloquia & Seminars

Conferences & Symposia

Other Invited Talks

 

 

 

 

University Colloquia & Seminars

 

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1.       Department of Physics Colloquium, Brandeis University, Waltham, MA, February 24, 2004.

2.       Department of Bioengineering, UCLA, Los Angeles, CA, "SIngle-Molecule Dynamics of Molecular Machines that Replicate DNA,"  January 21, 2004.

3.       Seminar Series on Quantum Optics and Molecular Applications, Princeton University, Princeton, NJ, December 4, 2003.

4.       Physics of Complex Systems, Division of Physics and Astronomy, Free University of Amsterdam, Amsterdam, The Netherlands, June 30, 2003.

5.       Institute for Microsystem Technology & the Nano-Physics Group, University of Freiburg, Germany, June 27, 2003.

6.       Department of Physics Colloquium, Zurich ETH, Zurich, Switzerland, June 25, 2003.

7.       Physical Electronics Laboratory, Zurich ETH, Zurich, Switzerland, June 24, 2003.

8.       “Tuning and Swtiching the DNA Polymerase Motor with Mechanical Tension,” Center for Genomics Research, Harvard University, Cambridge, MA, October, 2002.

9.       "Tuning DNA "Strings": Controlling the Speed (and Direction) of Molecular Engines that Replicate DNA," Complex Systems Center, Northeastern Physics Department, Boston, MA, October 23, 2001.

Conferences & Symposia

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1.       Advancing Beneficial Nanotechnology: Focusing on the Cutting Edge; 13th Foresight Conference on Advanced Nanotechnology, San Francisco, CA, October 26, 2005.

2.       Panelist, "Bob Metcalfe and the TR35," Technology Review's Emerging Technologies Conference at MIT, Boston, MA, September 28, 2005.

3.       Panelist, "Bio-Nano Frontiers," Technology Review's Emerging Technologies Conference at MIT, Boston, MA, September 28, 2005.

4.       World Technology Summit: Extraordinary Innovators Review, San Francisco, CA, October 7, 2004.

5.       Int’l Symposium on Elucidating Biomolecular Networks by Single-Molecule Technologies, Monte-Verita, Ascona, Switzerland, October 27, 2003.

6.       Opening keynote speaker, DARPA/DSO International Workshop on Biomolecular Motors as Building Blocks for Engineering Devices and Systems, San Francisco, CA, August 20, 2003.

7.       SPIE International Symposium on Fluctuations and Noise, Santa Fe, NM, June 2, 2003.

8.       Presented paper, “The Physics of Life,” at Young Researchers’ Competition (Finalist), Science and Ultimate Reality Symposium, Plainsboro, NJ, March, 2002. See also Physics Today, May 2002.

9.        “How to Modulate the Speed and Direction of Molecular Engines that Replicate DNA.” IBC First Meeting on Nanobiotechnology, San Diego, CA. July 16th-17th, 2001.

10.       Invited speaker on Future Technology Panel, Chaired by Dr. Phil Campbell, Editor-in-chief of Nature. World Technology Summit, London, UK, July 1-2, 2001.

11.       “Unifying Themes in Enzymatic Polymerization of DNA,” joint lecture with Prof. Tom Ellenberger, 12th Annual Conversation, sponsored by the Journal of Biomolecular Structure and Dynamics, Albany, NY, June 2001.

12.       "The Information Content of Single Molecule Experiments," 12th Annual Conversation, sponsored by the Journal of Biomolecular Structure and Dynamics, Albany, NY, June 2001.

Other Invited Talks

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1.       Osher Institute Banquet, Launching the Asian Medicine Program of Harvard Medical School, Cambridge, MA, February 16, 2005.

2.       “Emerging Prospects in Biocomputing,” Hughes Research Lab, Malibu, CA, February 11, 2005.

3.       The Cosmology and Cosmogony of Life: Contemporary Issues and Scope of Future Research on Life and Its Origin, Second International Congress on Life and Its Origin , Rome,
Italy, November 10-15, 2004.

4.       Clinical Pathology Conference, MGH Grand Rounds Presentation, Boston,MA, April, 2004 (to appear in New England Journal of Medicine).

5.       “Emerging Prospects in Nanobiotechnology,” TIE-Atlantic, Boston, MA, October,
2001.

6.       “Some Future Prospects for Interfacing Physics and Bio-Nanotechnology,” Nanotechnology Gathering on Openness in the Realms of “Stuff” and Bits , hosted by the Foresight Insitute, San Jose, CA, 1999 .