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Publications

  1. Gene regulatory functions can match the shape of Hill functions
    F. Wong, J. Estrada, Y. Shulgina, and J. Gunawardena
  2. Physics of antibiotic-mediated bacterial cell death
    F. Wong and A. Amir
  3. An energy-speed-accuracy trade-off in complex networks for biological discrimination
    F. Wong, A. Amir, and J. Gunawardena
    in review, 2017.
  4. MreB filaments create rod shape by aligning along principal membrane curvature
    S. Hussain*, C. N. Wivagg*, P. Szwedziak, F. Wong, K. Schaefer, T. Izoré, L. D. Renner, Y. Sun, A. W. Bisson-Filho, S. Walker, A. Amir, J. Löwe, and E. C. Garner
    in review, 2017.
  5. Mechanical strain sensing implicated in cell shape recovery in Escherichia coli
    F. Wong*, L. D. Renner*, G. Özbaykal, J. Paulose, D. B. Weibel, S. van Teeffelen, and A. Amir
    Nature Microbiology 2, 17115 (2017).
  6. [Nature Microbiology Community: Behind the Paper]
    [Biophysical Journal Poster Prize]

  7. Information integration and energy expenditure in gene regulation
    J. Estrada, F. Wong, A. DePace, and J. Gunawardena
    Cell 166, 234-244 (2016).
  8. A framework for modelling gene regulation which accommodates non-equilibrium mechanisms
    T. Ahsendorf*, F. Wong*, R. Eils, and J. Gunawardena
    BMC Biology 12, 102 (2014).
  9. [BMC Biology Commentary]
    *equal contributors

Research

I am a theorist and my research centers on two main themes:

Bacterial morphogenesis

How do bacteria regulate their shapes?
Many bacteria, including the rod-shaped Escherichia coli or the round Staphylococcus aureus, regulate their shapes during growth and in response to morphological perturbations with remarkable precision. Addressing this question theoretically can lead to insights into the cell wall remodeling process and antibiotic discovery.

Collaborators: Lars D. Renner, Sven van Teeffelen, and Ethan C. Garner

Information processing in biology

How is information transmitted in cells and what principles underlie energy expenditure in living systems?
Many biological processes such as proofreading in DNA replication or gene regulation in eukaryotes are known to be dissipative. Nonequilibrium statistical mechanics can elucidate what general limits there are to these processes and why energy expenditure is necessary for life.

Collaborators: Jeremy Gunawardena and Angela DePace

Contact

Felix Wong
School of Engineering and Applied Sciences
Harvard University
29 Oxford Street
Cambridge, MA 02138 USA
Office: Pierce 407

Email: fwong [at] g.harvard.edu

Research group website: http://amir.seas.harvard.edu/

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